The COVID-19 pandemic has highlighted the need for a multi-sector multi-stakeholder coordinated approach to public health emergencies. The ICAO Collaborative Arrangement for the Prevention and Management of Public Health Events in Civil Aviation (CAPSCA) programme, has followed this approach since its establishment in 2006, but it was not always well supported by ICAO Member States. The COVID-19 pandemic has highlighted the role of aviation medical experts in the management of public health emergencies. In this Skytalk the aviation medicine section will provide an overview of the framework, members and partners of CAPSCA, including the current governance structure. CAPSCA activities prior to, and during the COVID-19 pandemic will be discussed, as well as lessons learned from the COVID-19 pandemic. The talk will wrap up detailing new initiatives and future activities to strengthen CAPSCA and the aviation medical sector’s preparedness to respond to different types of health emergencies’ in future.